Amicidins
TM
Our first new class of
macro biologics
Amicidins™
Macro designs, patents, and produces advanced biomaterials for safer healthcare, clean food and water, and better packaging. Our first class – Amicidins – are biological polymers composed of amino acids and engineered to combine: i) beneficial physical properties; ii) broad microbicidal activity; and iii) safety for people and the environment. They are active against Gram-positive & Gram-negative bacteria, including multidrug-resistant organisms (MDROs), as well as Candida spp. Amicidin-α and Amicidin-β are purpose-built for local application to prevent and treat life-threatening infections.
The physical properties of Amicidins enable versatile product formulation and fabrication for diverse applications across multiple industries. These engineered macro biologics, alone and with excipients, can yield new products or improve existing ones. In healthcare, possibilities include breakthrough therapeutics, innovative medical devices, gentler veterinary & pet care products, and enhanced consumer health & cosmetic products. Development is currently underway to bring next-generation products to life to prevent and treat life-threatening infections, including those caused by antibiotic resistant microbes (see Pipeline).
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Our two lead Amicidins, Amicidin-α and Amicidin-β, are in multiple investigational products for the fields of surgery and trauma. Amicidin-α is the foundation for Amicidin-α Surgical and Amicidin-α PFC (Prolonged Field Care). Amicidin-β is the foundation for Amicidin-β Solution and Amicidin-β/EF (Extended Formulation; see Pipeline).
Looking to the future, single Amicidins are expected to yield multiple distinct products with diverse applications -- in some cases, across multiple industries. To learn more about corporate partnering opportunities, see Partnering.
A single Amicidin can yield multiple products
Manufacturing by
robust polymer methods
Macro's large molecule biologics are manufactured by robust polymer methods. Kilogram scale production under GMP guidelines has been achieved. This technology and approach should allow cost-effective manufacturing through commercial production at metric ton scale.
